A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

Thilo Winzer1,  Valeria Gazda1,  Zhesi He1,  Filip Kaminski1,  Marcelo Kern1,  Tony R. Larson1,  Yi Li1,  Fergus Meade1,  Roxana Teodor1,  Fabi·n E. Vaistij1,  Carol Walker2,  Tim A. Bowser2,  Ian A. Graham1,* Abstract Noscapine is an antitumor alkaloid from opium poppy that binds tubulin, arrests metaphase, and induces apoptosis in dividing human cells. Elucidation of the biosynthetic […]

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

Thilo Winzer, Valeria Gazda, Zhesi He, Filip Kaminski, Marcelo Kern, Tony R. Larson, Yi Li, Fergus Meade, Roxana Teodor, Fabián E. Vaistij, Carol Walker, Tim A. Bowser, Ian A. Graham* A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine 31 May 2012

Nature Genetics: A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

Padraic G Fallon, Takashi Sasaki, Aileen Sandilands, Linda E Campbell, Sean P Saunders, Niamh E Mangan, John J Callanan, Hiroshi Kawasaki, Aiko Shiohama, Akiharu Kubo, John P Sundberg, Richard B Presland, Philip Fleckman, Nobuyoshi Shimizu, Jun Kudoh, Alan D Irvine, Masayuki Amagai, & W H Irwin McLean View Article May 5,2009