Science: A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine.
Noscapine is an antitumor alkaloid from opium poppy that binds tubulin, arrests metaphase, and induces apoptosis in dividing human cells. Elucidation of the biosynthetic pathway will enable improvement in commercial production of noscapine and related bioactive molecules. Transcriptomic analysis revealed … Continued